
FRIDAY, June 19 (HealthDay News) -- A key element in the development of chronic asthma has been identified by British researchers, who suggest that their finding may lead to new treatments.
The study by a team from King's College London and Imperial College London helps explain why the structure and function of airways in people with asthma are remodeled and how these changes contribute to chronic asthma.
"It is widely believed that this remodeling in asthma is in large part responsible for the chronicity of the disease. There are many features responsible for remodeling, but a key component of this process involves an increased amount of smooth muscle in the airways," study leader Dr. Tak Lee, head of the division of asthma and allergy research at King's College, said in a news release from the college.
The study appears in this week's online issue of the Proceedings of the National Academy of Sciences.
"This research into the causes of asthma provides us with vital clues as to how such symptoms could be stopped and it has uncovered important information, which we hope will lead to the creation of effective new treatments for the millions of people in the U.K. affected by asthma symptoms," Dr. Elaine Vickers, research relations manager at Asthma U.K., said in the news release.
More information
The U.S. National Heart, Lung and Blood Institute has more about asthma.

TUESDAY, May 26 (HealthDay News) -- As the H1N1 swine flu virus continues to wax and wane in different parts of the country, U.S. health officials said Tuesday that they were working as fast as possible to learn as much as they can about the novel pathogen before the return of the flu season in the fall.
The reason for the urgency: Some past pandemics were preceded by "herald waves" of a flu strain that surfaced at the end of one flu season, only to return with far greater consequences the next flu season.
"We are mindful that pandemics of influenza have sometimes come in waves," Dr. Anne Schuchat, the U.S. Centers for Disease Control and Prevention's interim deputy director for science and public health program, said during an afternoon news conference. "The very severe 1918 pandemic had a moderate herald wave in the spring and a much more severe second wave in the fall. So that very terrible experience of 1918 is in our minds."
Some estimates have placed the worldwide death toll from the 1918 outbreak -- often referred to as the "Spanish Flu" -- as high as 40 million people.
"We are really on a fast track, over the next to eight to 10 weeks, to learn as much as we can as this virus heads to the Southern Hemisphere [where flu season is just beginning] and to strengthen our planning for the surge of illness that we expect to experience here in the fall," Schuchat added.
Scientists will be looking to see if the H1N1 swine flu virus mutates or becomes resistant to antiviral medications, or is more easily spread among people, she said.
Schuchat said there's no way to tell now if the H1N1 virus will be more virulent when -- and if -- it returns to the Northern Hemisphere with the approach of winter. "Whether it will dominate among the seasonal flu viruses or whether it will disappear is not predictable right now," she said.
To date there have been 6,764 confirmed and probable cases of infection in the United States, Schuchat said, adding that most of the cases have been mild and patients have recovered quickly.
The CDC is reporting 11 deaths linked to the swine flu, and all of the victims had underlying health problems before they were infected. Illinois health officials reported the death of a Chicago area man over the weekend.
Canadian officials said Monday that a Toronto man who had swine flu died Saturday, and he also suffered from a chronic medical condition.
The World Health Organization said Tuesday that 46 countries have reported 12,954 cases of H1N1 swine flu infection, including 92 deaths, most of them in Mexico, where the outbreak began.
The CDC said last week that progress was being made toward the development of an H1N1 swine flu vaccine, with two promising candidate viruses for use in such a shot. And U.S. Department of Health and Human Services Secretary Kathleen Sebelius said Friday that the federal government was allocating $1 billion to the search for a swine flu vaccine.
In the United States, most cases of the swine flu continue to be no worse than seasonal flu. Testing has found that the swine flu virus remains susceptible to two common antiviral drugs, Tamiflu and Relenza, according to the CDC.
The CDC says some older people may have partial immunity to the H1N1 swine flu virus because of possible exposure to another H1N1 flu strain circulating prior to 1957. So far, 64 percent of cases of swine flu infection in the United States have been among people aged 5 to 24, while only 1 percent involves people over 65, officials said last week.
U.S. Human Cases of H1N1 Flu Infection
(As of May 25, 2009, 11:00 AM ET) |
| States |
# of
confirmed and probable
cases |
Deaths |
Alabama |
66 |
|
Arkansas |
4 |
|
Arizona |
531 |
3 deaths |
California |
553 |
|
Colorado |
60 |
|
Connecticut |
102 cases |
|
Delaware |
102 |
|
Florida |
139 |
|
Georgia |
28 |
|
Hawaii |
40 |
|
Idaho |
9 |
|
Illinois |
896 |
|
Indiana |
120 cases |
|
Iowa |
71 |
|
Kansas |
34 |
|
Kentucky** |
27 |
|
Louisiana |
86 |
|
Maine |
9 |
|
Maryland |
41 |
|
Massachusetts |
238 |
|
Michigan |
176 |
|
Minnesota |
44 |
|
Mississippi |
7 cases |
|
Missouri |
24 |
1 deaths |
Montana |
12 |
|
Nebraska |
29 |
|
Nevada |
49 cases |
|
New Hampshire |
23 |
|
New Jersey |
29 |
|
New Mexico |
97 |
|
New York |
343 |
1 deaths |
North Carolina |
12 |
|
North Dakota |
6 |
|
Ohio |
14 |
|
Oklahoma |
51 |
|
Oregon |
116 |
|
Pennsylvania |
88 |
|
Rhode Island |
10 |
|
South Carolina |
36 |
|
South Dakota |
3 |
|
Tennessee |
94 |
|
Texas |
900 |
3 deaths |
Utah |
122 |
1 deaths |
Vermont |
2 |
|
Virginia |
25 |
|
Washington |
517 |
1 death |
Washington, D.C. |
13 |
|
Wisconsin |
766 |
|
TOTAL*(48) |
6,764 cases |
10 deaths |
*includes the District of Columbia
**One case is resident of Ky. but hospitalized in Ga.
Source: U.S. Centers for Disease Control and Prevention
|
|
More information
For more on swine flu, visit the U.S. Centers for Disease Control and Prevention.